Changes to z score Limits

As a result of an internal review, we have taken the decision to adjust the performance monitoring limits for quantitative programmes.

These will be rolled out on an ongoing basis until all such quantitative programmes are amended.

Listed below are the current quantitative programmes where the changes have been made.  This will be updated as and when changes to any programmes are made and show the trial and date when the changes came into effect.


Programme Trial Effective From
BCR-ABL1 Major Quantification        161702 13/09/2016
Post SCT Chimerism Monitoring        161703 26/10/2016
Low Level Leucocyte Enumeration        161708 16/01/2017
CD34+ Stem Cell Enumeration        161705 23/01/2017

Immune Monitoring Alternative Technologies

161705 24/01/2017
Minimal Residual Disease for Acute Lymphoblastic Leukaemia        161704 24/01/2017
Immune Monitoring        161705 30/01/2017
Pilot Minimal Residual Disease in AML     161703  07/02/2017
Pilot Minimal Residual Disease in CLL        161703 13/02/2017
Leukaemia Immunophenotyping (Part 1)        161705 21/02/2017


The changes to the performance limits detailed below will be applicable to all quantitative programmes appearing in the above list unless otherwise specified.

• A result between 2.5 and -2.5 will now be classed as satisfactory

• A result between >2.5 and 3.5 or <-2.5 and -3.5 will be classed as an 'Action’ result. An ‘Action’ category highlights a potential issue to the laboratory and indicates that the laboratory should review. Two ‘Action’ results in a period of 3 samples would result in classification as a ‘Critical’

• A result above 3.5 or below -3.5 is considered to be a ‘critical’ result requiring immediate investigation by the laboratory

Please note that if you are a UK-based laboratory the relevant National Quality Assurance Advisory Panel will be automatically notified when a Critical level of performance is assigned. Non-UK laboratories are not notified to UK NQAAP’s.

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Last updated 6th April 2017 © UK NEQAS for Leucocyte Immunophenotyping not to be reproduced in all or part without permission.