Recent publications have shown that all cases of Hairy Cell Leukaemia harbour the BRAF V600E mutation. The analysis of BRAF V600E has the potential to become a useful tool in the differential diagnosis of mature B-cell neoplasms.
In this programme, participants are provided with lyophilised cell-lines for BRAF V600E mutation status analysis. Participants are asked to submit qualitative results, together with details of the methodology. Instructions for storage, reconstitution and use of the lyophilised samples are included with the samples. Three send-outs are issued per annum, with each send-out consisting of two samples.
Pre issue testing of samples for this programme is subcontracted, although the final decision about sample suitability lies with the EQA provider; no other activities in relation to this EQA programme are subcontracted.