Myeloproliferative Neoplasm Gene Panels (Pilot - Not Accredited)

 

Please note, programme name to be changed to Myeloproliferative Neoplasms Diagnostic Testing (Pilot - Not Accredited) on 1st April 2022.

 

This scheme is designed for laboratories performing gene panel testing in Myeloproliferative Neoplasms using current diagnostic algorithms (Tefferi & Pardanani, 2014) to diagnose and subtype the disease. One sample will be issued per round (1 round per year) alongside clinical scenarios and laboratories will be expected to test the samples according to the current testing pathways. Participants will primarily be expected to test the samples for known JAK2 (V617F and exon 12), CALR exon 9 and MPL exon 10 pathogenic variants, although testing of all of these genes is not mandatory.

 

In addition participants will be able to use more extensive Next Generation Sequencing (NGS) MPN panels and report any pathogenic intragenic and/or regulatory element changes such as point mutations, small insertion, deletion and duplication events. Participants will not be requested to report larger changes affecting genome architecture or copy number changes (>50kb). 

 

**** New for 2022-2023*** Myeloproliferative Neoplasm Gene Panels (Pilot – Not Accredited) will be renamed Myeloproliferative Neoplasm Diagnostic Testing (Pilot – Not Accredited) and will be limited to testing of JAK2 p.Val617Phe, JAK2 exon 12, CALR exon 9 and MPL exon 10 variant as per WHO/NCCN guidance. Extended next generation sequencing panel data will be incorporated into the new Myeloid Gene Panels (Pilot – Not Accredited) programme – see relevant programme page for further details.

 

To register for this programme, please click here.

Example MPN GP Report
MPN GP 202101 Report Example.pdf
Adobe Acrobat document [909.3 KB]
Pre-Pilot MPN GP (Not Accredited) 192001 Data Entry Form
Pilot MPN Gene Panels 202101 (not accred[...]
Adobe Acrobat document [1.7 MB]
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Last updated 15/12/2021 © UK NEQAS for Leucocyte Immunophenotyping not to be reproduced in all or part without permission.

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