BRAF p.Val600Glu (V600E) Mutation Status for Hairy Cell Leukaemia (Accredited)


Programme objective  To assess a laboratory’s ability to accurately detect the NM_004333.6(BRAF):c.1799T>A p.(Val600Glu) variant.

 

Clinical/scientific background  Publications have shown that all cases of Hairy Cell Leukaemia harbour the BRAF p.(Val600Glu) variant. The analysis of BRAF p.(Val600Glu) is a useful tool in the differential diagnosis of mature B-cell neoplasms.

 

Suitability  Any molecular genetic approach for the detection of  BRAF c.1799T>A p.(Val600Glu).

 

Sample type/distribution  Two lyophilised cell line-based samples are issued three times per annum. Participants are asked to submit qualitative results together with details of the methodology used. Instructions for storage, reconstitution and use of the lyophilised samples are included with the samples.  The trial schedule can be found here: https://www.ukneqasli.co.uk/eqa-pt-programmes/trial-schedules/

 

Trial duration  Trials for this programme are live/open for a minimum of four weeks. Please note, trials issued/closing in August or December are extended by one week. An automated email is sent two days prior to the trial closing, to any participant that has not returned results, warning them of the trial closure date.

 

Subcontracted areas  Pre-issue and post-closure testing of samples for this programme are subcontracted, although the final decision about sample suitability lies with the EQA provider; no other activities in relation to this EQA programme are subcontracted.

 

Updates to the programme for current or upcoming year  Periodically we give laboratories the option of returning quantitative results. Whilst this allows participants to compare their results with the trial statistics, it is not currently a compulsory part of the programme, nor is it subject to performance monitoring. 

 

To register for this programme, please click here.

 

Example BRAF p.Val600Glu (V600E) Mutation Status for Hairy Cell Leukaemia Report
BRAF 222302 Report v1.0.0.pdf
Adobe Acrobat document [868.4 KB]
BRAF p.Val600Glu (V600E) Mutation Status for Hairy Cell Leukaemia Performance Monitoring System
Molecular 477__v1.3__PREVIEW.pdf
Adobe Acrobat document [78.6 KB]
Cover Letter BRAF 252601
Cover letter BRAF 252601.pdf
Adobe Acrobat document [134.9 KB]
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Last updated 26/02/2025 © UK NEQAS for Leucocyte Immunophenotyping not to be reproduced in all or part without permission.

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