Lymphoid Gene Panels (Pilot - Not Accredited)


Please note, programme name to be changed to Lymphoid Gene Panels (Pilot - Not Accredited) on 1st April 2022.


Chronic Lymphocytic Leukaemia (CLL) is an extremely heterogeneous haematological neoplasm of B-lymphocytes. Some patients never require therapy whilst others frequently relapse, partly attributable to recurrent genomic aberrations of prognostic significance identified by Next Generation Sequencing (NGS). Recently, the implementation of targeted gene panel NGS in CLL in their clinical setting has improved prognostication of patients.


Recent publication of the National Institute for Clinical Excellence guidelines for improving outcomes in haematological cancer (NG47 guidelines) and the publication of the national genomic test directory within the UK promote the harmonisation of testing pathways available to patients across the United Kingdom.


One sample will be issued per round (1 round per year). Participants will be asked to test the sample with their relevant in house CLL panel and report any clinically relevant intragenic and/or regulatory elemnt changes such as point mutations, small insertion, deletion and duplication events. Participants will not be requested to report larger changes affecting genome architecture or copy number changes (>50kb).


***NEW IN 2022-2023*** For the financial year 2022-2023 the Chronic Lymphocytic Leukaemia Gene Panels (Pilot – Not Accredited) will expand to encompass a broader range of lymphoid malignancies (e.g. acute lymphoblastic leukaemia, plasma cell dyscrasia, diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma) which will necessitate a name change to Lymphoid Gene Panels. The number of distributions issued will increase to two per annum, with clinical scenarios included to guide panel/bioinformatic analysis.


To register for this programme, please click here.

Lymphoid GP 232401 cover letter
Cover letter Lymphoid GP 232401.pdf
Adobe Acrobat document [102.4 KB]
Example Lymphoid GP Report
Lymphoid GP 222301 Example Report v1.0.0[...]
Adobe Acrobat document [341.4 KB]
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Last updated 28/11/2023 © UK NEQAS for Leucocyte Immunophenotyping not to be reproduced in all or part without permission.

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